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- Title
Dissecting complex transcriptional responses using pathway-level scores based on prior information.
- Authors
Bussemaker, Harmen J; Ward, Lucas D; Boorsma, Andre
- Abstract
The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathways to changes in the environment of the cells. The use of prior information, either about the function of the protein encoded by each gene, or about the physical interactions between regulatory factors and the sequences controlling its expression, has emerged as a powerful approach for dissecting complex transcriptional responses.
- Publication
BMC bioinformatics, 2007, Vol 8 Suppl 6, pS6
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-8-S6-S6