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- Title
Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases.
- Authors
Tkaczuk, Karolina L; Dunin-Horkawicz, Stanislaw; Purta, Elzbieta; Bujnicki, Janusz M
- Abstract
SPOUT methyltransferases (MTases) are a large class of S-adenosyl-L-methionine-dependent enzymes that exhibit an unusual alpha/beta fold with a very deep topological knot. In 2001, when no crystal structures were available for any of these proteins, Anantharaman, Koonin, and Aravind identified homology between SpoU and TrmD MTases and defined the SPOUT superfamily. Since then, multiple crystal structures of knotted MTases have been solved and numerous new homologous sequences appeared in the databases. However, no comprehensive comparative analysis of these proteins has been carried out to classify them based on structural and evolutionary criteria and to guide functional predictions.
- Publication
BMC bioinformatics, 2007, Vol 8, p73
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-8-73