We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Background frequencies for residue variability estimates: BLOSUM revisited.
- Authors
Mihalek, I; Res, I; Lichtarge, O
- Abstract
Shannon entropy applied to columns of multiple sequence alignments as a score of residue conservation has proven one of the most fruitful ideas in bioinformatics. This straightforward and intuitively appealing measure clearly shows the regions of a protein under increased evolutionary pressure, highlighting their functional importance. The inability of the column entropy to differentiate between residue types, however, limits its resolution power.
- Publication
BMC bioinformatics, 2007, Vol 8, p488
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-8-488