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- Title
Tools for integrated sequence-structure analysis with UCSF Chimera.
- Authors
Meng, Elaine C; Pettersen, Eric F; Couch, Gregory S; Huang, Conrad C; Ferrin, Thomas E
- Abstract
Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many programs exist for individual aspects of such work, there is a need for interactive visualization tools that: (a) provide a deep integration of sequence and structure, far beyond mapping where a sequence region falls in the structure and vice versa; (b) facilitate changing data of one type based on the other (for example, using only sequence-conserved residues to match structures, or adjusting a sequence alignment based on spatial fit); (c) can be used with a researcher's own data, including arbitrary sequence alignments and annotations, closely or distantly related sets of proteins, etc.; and (d) interoperate with each other and with a full complement of molecular graphics features. We describe enhancements to UCSF Chimera to achieve these goals.
- Publication
BMC bioinformatics, 2006, Vol 7, p339
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-7-339