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- Title
Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation.
- Authors
Lee, Jamie A; Sinkovits, Robert S; Mock, Dennis; Rab, Eva L; Cai, Jennifer; Yang, Peng; Saunders, Brian; Hsueh, Robert C; Choi, Sangdun; Subramaniam, Shankar; Scheuermann, Richard H; Alliance for Cellular Signaling
- Abstract
Activation of naïve B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccharide (LPS) and CD40 ligand, induces a combination of common and ligand-specific phenotypic changes through complex signal transduction pathways. For example, although all three of these ligands induce proliferation, only stimulation through the B cell antigen receptor (BCR) induces apoptosis in resting splenic B cells. In order to define the common and unique biological responses to ligand stimulation, we compared the gene expression changes induced in normal primary B cells by a panel of ligands using cDNA microarrays and a statistical approach, CLASSIFI (Cluster Assignment for Biological Inference), which identifies significant co-clustering of genes with similar Gene Ontology annotation.
- Publication
BMC bioinformatics, 2006, Vol 7, p237
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-7-237