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- Title
XcisClique: analysis of regulatory bicliques.
- Authors
Pati, Amrita; Vasquez-Robinet, Cecilia; Heath, Lenwood S; Grene, Ruth; Murali, T M
- Abstract
Modeling of cis-elements or regulatory motifs in promoter (upstream) regions of genes is a challenging computational problem. In this work, set of regulatory motifs simultaneously present in the promoters of a set of genes is modeled as a biclique in a suitably defined bipartite graph. A biologically meaningful co-occurrence of multiple cis-elements in a gene promoter is assessed by the combined analysis of genomic and gene expression data. Greater statistical significance is associated with a set of genes that shares a common set of regulatory motifs, while simultaneously exhibiting highly correlated gene expression under given experimental conditions.
- Publication
BMC bioinformatics, 2006, Vol 7, p218
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-7-218