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- Title
MUSCLE: a multiple sequence alignment method with reduced time and space complexity.
- Authors
Edgar, Robert C
- Abstract
In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUSCLE to achieve the highest scores reported to date on four alignment accuracy benchmarks. Here we present a more complete discussion of the algorithm, describing several previously unpublished techniques that improve biological accuracy and / or computational complexity. We introduce a new option, MUSCLE-fast, designed for high-throughput applications. We also describe a new protocol for evaluating objective functions that align two profiles.
- Publication
BMC bioinformatics, 2004, Vol 5, p113
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-5-113