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- Title
Tests for finding complex patterns of differential expression in cancers: towards individualized medicine.
- Authors
Lyons-Weiler, James; Patel, Satish; Becich, Michael J; Godfrey, Tony E
- Abstract
Microarray studies in cancer compare expression levels between two or more sample groups on thousands of genes. Data analysis follows a population-level approach (e.g., comparison of sample means) to identify differentially expressed genes. This leads to the discovery of 'population-level' markers, i.e., genes with the expression patterns A > B and B > A. We introduce the PPST test that identifies genes where a significantly large subset of cases exhibit expression values beyond upper and lower thresholds observed in the control samples.
- Publication
BMC bioinformatics, 2004, Vol 5, p110
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-5-110