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- Title
Utilizing protein structure to identify non-random somatic mutations.
- Authors
Ryslik, Gregory A; Cheng, Yuwei; Cheung, Kei-Hoi; Modis, Yorgo; Zhao, Hongyu
- Abstract
Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible for tumorigenesis. As there have been significant pharmacological successes in developing drugs that treat cancers that carry these driver mutations, several methods that rely on mutational clustering have been developed to identify them. However, these methods consider proteins as a single strand without taking their spatial structures into account. We propose an extension to current methodology that incorporates protein tertiary structure in order to increase our power when identifying mutation clustering.
- Publication
BMC bioinformatics, 2013, Vol 14, p190
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-14-190