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- Title
Exploiting ancestral mammalian genomes for the prediction of human transcription factor binding sites.
- Authors
Blanchette, Mathieu
- Abstract
The computational prediction of Transcription Factor Binding Sites (TFBS) remains a challenge due to their short length and low information content. Comparative genomics approaches that simultaneously consider several related species and favor sites that have been conserved throughout evolution improve the accuracy (specificity) of the predictions but are limited due to a phenomenon called binding site turnover, where sequence evolution causes one TFBS to replace another in the same region. In parallel to this development, an increasing number of mammalian genomes are now sequenced and it is becoming possible to infer, to a surprisingly high degree of accuracy, ancestral mammalian sequences.
- Publication
BMC bioinformatics, 2012, Vol 13 Suppl 19, pS2
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-13-S19-S2