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- Title
A methodology for detecting the orthology signal in a PPI network at a functional complex level.
- Authors
Jancura, Pavol; Mavridou, Eleftheria; Carrillo-de Santa Pau, Enrique; Marchiori, Elena
- Abstract
Stable evolutionary signal has been observed in a yeast protein-protein interaction (PPI) network. These finding suggests more connected regions of a PPI network to be potential mediators of evolutionary information. Because more connected regions of PPI networks contain functional complexes, we are motivated to exploit the orthology relation for identifying complexes that can be clearly attributed to such evolutionary signal.
- Publication
BMC bioinformatics, 2012, Vol 13 Suppl 10, pS18
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-13-S10-S18