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- Title
Normalizing for individual cell population context in the analysis of high-content cellular screens.
- Authors
Knapp, Bettina; Rebhan, Ilka; Kumar, Anil; Matula, Petr; Kiani, Narsis A; Binder, Marco; Erfle, Holger; Rohr, Karl; Eils, Roland; Bartenschlager, Ralf; Kaderali, Lars
- Abstract
High-content, high-throughput RNA interference (RNAi) offers unprecedented possibilities to elucidate gene function and involvement in biological processes. Microscopy based screening allows phenotypic observations at the level of individual cells. It was recently shown that a cell's population context significantly influences results. However, standard analysis methods for cellular screens do not currently take individual cell data into account unless this is important for the phenotype of interest, i.e. when studying cell morphology.
- Publication
BMC bioinformatics, 2011, Vol 12, p485
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-12-485