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- Title
Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis.
- Authors
Garg, Aarti; Tewari, Rupinder; Raghava, Gajendra P S
- Abstract
An explosive global spreading of multidrug resistant Mycobacterium tuberculosis (Mtb) is a catastrophe, which demands an urgent need to design or develop novel/potent antitubercular agents. The Lysine/DAP biosynthetic pathway is a promising target due its specific role in cell wall and amino acid biosynthesis. Here, we report identification of potential antitubercular candidates targeting Mtb dihydrodipicolinate synthase (DHDPS) enzyme of the pathway using virtual screening protocols.
- Publication
BMC bioinformatics, 2010, Vol 11 Suppl 1, pS53
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-S1-S53