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- Title
An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs.
- Authors
Garcia-Alcalde, Fernando; Blanco, Armando; Shepherd, Adrian J
- Abstract
Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of predicting the location of known TFBS motifs in a given DNA sequence. It has previously been shown that, when scoring matches to known TFBS motifs, interdependencies between positions within a motif should be taken into account. However, this remains a challenging task owing to the fact that sequences similar to those of known TFBSs can occur by chance with a relatively high frequency. Here we present a new method for matching sequences to TFBS motifs based on intuitionistic fuzzy sets (IFS) theory, an approach that has been shown to be particularly appropriate for tackling problems that embody a high degree of uncertainty.
- Publication
BMC bioinformatics, 2010, Vol 11, p551
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-551