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- Title
pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree.
- Authors
Matsen, Frederick A; Kodner, Robin B; Armbrust, E Virginia
- Abstract
Likelihood-based phylogenetic inference is generally considered to be the most reliable classification method for unknown sequences. However, traditional likelihood-based phylogenetic methods cannot be applied to large volumes of short reads from next-generation sequencing due to computational complexity issues and lack of phylogenetic signal. "Phylogenetic placement," where a reference tree is fixed and the unknown query sequences are placed onto the tree via a reference alignment, is a way to bring the inferential power offered by likelihood-based approaches to large data sets.
- Publication
BMC bioinformatics, 2010, Vol 11, p538
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-538