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- Title
Formalization of taxon-based constraints to detect inconsistencies in annotation and ontology development.
- Authors
Deegan née Clark, Jennifer I; Dimmer, Emily C; Mungall, Christopher J
- Abstract
The Gene Ontology project supports categorization of gene products according to their location of action, the molecular functions that they carry out, and the processes that they are involved in. Although the ontologies are intentionally developed to be taxon neutral, and to cover all species, there are inherent taxon specificities in some branches. For example, the process 'lactation' is specific to mammals and the location 'mitochondrion' is specific to eukaryotes. The lack of an explicit formalization of these constraints can lead to errors and inconsistencies in automated and manual annotation.
- Publication
BMC bioinformatics, 2010, Vol 11, p530
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-530