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- Title
HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data.
- Authors
Qin, Zhaohui S; Yu, Jianjun; Shen, Jincheng; Maher, Christopher A; Hu, Ming; Kalyana-Sundaram, Shanker; Yu, Jindan; Chinnaiyan, Arul M
- Abstract
Protein-DNA interaction constitutes a basic mechanism for the genetic regulation of target gene expression. Deciphering this mechanism has been a daunting task due to the difficulty in characterizing protein-bound DNA on a large scale. A powerful technique has recently emerged that couples chromatin immunoprecipitation (ChIP) with next-generation sequencing, (ChIP-Seq). This technique provides a direct survey of the cistrom of transcription factors and other chromatin-associated proteins. In order to realize the full potential of this technique, increasingly sophisticated statistical algorithms have been developed to analyze the massive amount of data generated by this method.
- Publication
BMC bioinformatics, 2010, Vol 11, p369
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-369