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- Title
Detecting microRNA activity from gene expression data.
- Authors
Madden, Stephen F; Carpenter, Susan B; Jeffery, Ian B; Björkbacka, Harry; Fitzgerald, Katherine A; O'Neill, Luke A; Higgins, Desmond G
- Abstract
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or inducing mRNA degradation. A number of computational techniques have been developed to identify the targets of miRNAs. In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions.
- Publication
BMC bioinformatics, 2010, Vol 11, p257
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-257