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- Title
An optimized TOPS+ comparison method for enhanced TOPS models.
- Authors
Veeramalai, Mallika; Gilbert, David; Valiente, Gabriel
- Abstract
Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a high degree of biological significance. Previously we have discussed the basic mechanisms of our novel method for structure comparison based on our TOPS+ model (Topological descriptions of Protein Structures Enhanced with Ligand Information). In this paper we show how these results can be significantly improved using parameter optimization, and we call the resulting optimised TOPS+ method as advanced TOPS+ comparison method i.e. advTOPS+.
- Publication
BMC bioinformatics, 2010, Vol 11, p138
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-11-138