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- Title
Could a defective epithelial sodium channel lead to bronchiectasis.
- Authors
Fajac, Isabelle; Viel, Marion; Sublemontier, Sébastien; Hubert, Dominique; Bienvenu, Thierry
- Abstract
Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mutations in the CFTR gene and causing bronchiectasis in the airways. Moreover, it was found that transgenic mice overexpressing ENaCbeta present cystic fibrosis-like lung disease symptoms. Our aim was to evaluate if a defective ENaC protein could be involved in the development of bronchiectasis.
- Publication
Respiratory research, 2008, Vol 9, p46
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-9-46