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- Title
Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation.
- Authors
Maarsingh, Harm; Tio, Marieke A; Zaagsma, Johan; Meurs, Herman
- Abstract
Recent evidence suggests that endogenous arginase activity potentiates airway responsiveness to methacholine by attenuation of agonist-induced nitric oxide (NO) production, presumably by competition with epithelial constitutive NO synthase for the common substrate, L-arginine. Using guinea pig tracheal open-ring preparations, we now investigated the involvement of arginase in the modulation of neuronal nitric oxide synthase (nNOS)-mediated relaxation induced by inhibitory nonadrenergic noncholinergic (iNANC) nerve stimulation.
- Publication
Respiratory research, 2005, Vol 6, p23
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-6-23