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- Title
Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells.
- Authors
Chan, M C W; Cheung, C Y; Chui, W H; Tsao, S W; Nicholls, J M; Chan, Y O; Chan, R W Y; Long, H T; Poon, L L M; Guan, Y; Peiris, J S M
- Abstract
Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum levels of IP-10 (interferon-gamma-inducible protein-10). Furthermore, when compared with human influenza virus subtype H1N1, the H5N1 viruses in 1997 (A/Hong Kong/483/97) (H5N1/97) were more potent inducers of pro-inflammatory cytokines (e.g. tumor necrosis factor-a) and chemokines (e.g. IP-10) from primary human macrophages in vitro, which suggests that cytokines dysregulation may play a role in pathogenesis of H5N1 disease. Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells.
- Publication
Respiratory research, 2005, Vol 6, p135
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-6-135