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- Title
Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis.
- Authors
Raju, S Vamsee; Tate, Jody H; Peacock, Sandra K G; Fang, Ping; Oster, Robert A; Dransfield, Mark T; Rowe, Steven M
- Abstract
Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is variable and the underlying genetic contributors remain unclear. We hypothesized that presence of CFTR mutation heterozygosity may alter susceptibility to cigarette smoke induced CFTR dysfunction. Consequently, COPD patients with chronic bronchitis may have a higher rate of CFTR mutations compared to the general population.
- Publication
Respiratory research, 2014, Vol 15, p18
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-15-18