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- Title
RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.
- Authors
Didon, Lukas; Zwick, Rachel K; Chao, Ion Wa; Walters, Matthew S; Wang, Rui; Hackett, Neil R; Crystal, Ronald G
- Abstract
Ciliated cells play a central role in cleansing the airways of inhaled contaminants. They are derived from basal cells that include the airway stem/progenitor cells. In animal models, the transcription factor FOXJ1 has been shown to induce differentiation to the ciliated cell lineage, and the RFX transcription factor-family has been shown to be necessary for, but not sufficient to induce, correct cilia development.
- Publication
Respiratory research, 2013, Vol 14, p70
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-14-70