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- Title
Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia.
- Authors
Evans, Scott E; Tuvim, Michael J; Zhang, Jiexin; Larson, Derek T; García, Cesar D; Martinez-Pro, Sylvia; Coombes, Kevin R; Dickey, Burton F
- Abstract
Lower respiratory tract infections continue to exact unacceptable worldwide mortality, often because the infecting pathogen cannot be identified. The respiratory epithelia provide protection from pneumonias through organism-specific generation of antimicrobial products, offering potential insight into the identity of infecting pathogens. This study assesses the capacity of the host gene expression response to infection to predict the presence and identity of lower respiratory pathogens without reliance on culture data.
- Publication
Respiratory research, 2010, Vol 11, p101
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-11-101