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- Title
Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency.
- Authors
Parr, David G; Dirksen, Asger; Piitulainen, Eeva; Deng, Chunqin; Wencker, Marion; Stockley, Robert A
- Abstract
Computed tomography (CT) lung densitometry has been demonstrated to be the most sensitive and specific outcome measure for the assessment of emphysema-modifying therapy, but the optimum densitometric index has yet to be determined and targeted sampling may be more sensitive than whole lung assessment. The EXAcerbations and CT scan as Lung Endpoints (EXACTLE) trial aimed to clarify the optimum approach to the use of CT densitometry data for the assessment of alpha 1-antitrypsin (AAT) augmentation therapy on the progression of emphysema in AAT deficiency (AATD).
- Publication
Respiratory research, 2009, Vol 10, p75
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-10-75