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- Title
Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice.
- Authors
Clement, Cecilia G; Tuvim, Michael J; Evans, Christopher M; Tuvin, Daniel M; Dickey, Burton F; Evans, Scott E
- Abstract
Protective host responses to respiratory pathogens are typically characterized by inflammation. However, lung inflammation is not always protective and it may even become deleterious to the host. We have recently reported substantial protection against Streptococcus pneumoniae (pneumococcal) pneumonia by induction of a robust inflammatory innate immune response to an inhaled bacterial lysate. Conversely, the allergic inflammation associated with asthma has been proposed to promote susceptibility to pneumococcal disease. This study sought to determine whether preexisting allergic lung inflammation influences the progression of pneumococcal pneumonia or reduces the inducibilty of protective innate immunity against bacteria.
- Publication
Respiratory research, 2009, Vol 10, p70
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-10-70