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- Title
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.
- Authors
Raby, Benjamin A; Van Steen, Kristel; Lasky-Su, Jessica; Tantisira, Kelan; Kaplan, Feige; Weiss, Scott T
- Abstract
Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates nuclear entry of GR. In airway epithelial cells, inhibition of IPO13 expression prevents nuclear entry of GR and abrogates anti-inflammatory effects of glucocorticoids. Impaired nuclear entry of GR has been documented in steroid-non-responsive asthmatics. We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20).
- Publication
Respiratory research, 2009, Vol 10, p67
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-10-67