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- Title
Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma.
- Authors
Anderson, Sandra D; Charlton, Brett; Weiler, John M; Nichols, Sara; Spector, Sheldon L; Pearlman, David S; A305 Study Group
- Abstract
Asthma can be difficult to diagnose, but bronchial provocation with methacholine, exercise or mannitol is helpful when used to identify bronchial hyperresponsiveness (BHR), a key feature of the disease. The utility of these tests in subjects with signs and symptoms of asthma but without a clear diagnosis has not been investigated. We investigated the sensitivity and specificity of mannitol to identify exercise-induced bronchoconstriction (EIB) as a manifestation of BHR; compared this with methacholine; and compared the sensitivity and specificity of mannitol and methacholine for a clinician diagnosis of asthma.
- Publication
Respiratory research, 2009, Vol 10, p4
- ISSN
1465-993X
- Publication type
Journal Article
- DOI
10.1186/1465-9921-10-4