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- Title
Immunogenic properties of amyloid beta oligomers.
- Authors
Dalgediene, Indre; Lasickiene, Rita; Budvytyte, Rima; Valincius, Gintaras; Morkuniene, Ramune; Borutaite, Vilmante; Zvirbliene, Aurelija
- Abstract
The central molecule in the pathogenesis of Alzheimer's disease (AD) is believed to be a small-sized polypeptide - beta amyloid (Aβ) which has an ability to assemble spontaneously into oligomers. Various studies concerning therapeutic and prophylactic approaches for AD are based on the immunotherapy using antibodies against Aβ. It has been suggested that either active immunization with Aβ or passive immunization with anti-Aβ antibodies might help to prevent or reduce the symptoms of the disease. However, knowledge on the mechanisms of Aβ-induced immune response is rather limited. Previous research on Aβ1-42 oligomers in rat brain cultures showed that the neurotoxicity of these oligomers considerably depends on their size. In the current study, we evaluated the dependence of immunogenicity of Aβ1-42 oligomers on the size of oligomeric particles and identified the immunodominant epitopes of the oligomers.
- Publication
Journal of biomedical science, 2013, Vol 20, p10
- ISSN
1423-0127
- Publication type
Journal Article
- DOI
10.1186/1423-0127-20-10