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- Title
Growth inhibition of androgen-responsive prostate cancer cells with brefeldin A targeting cell cycle and androgen receptor.
- Authors
Rajamahanty, Srinivas; Alonzo, Catherine; Aynehchi, Shahrad; Choudhury, Muhammad; Konno, Sensuke
- Abstract
Androgen ablation is one of the viable therapeutic options for patients with primary hormone (androgen)-dependent prostate cancer. However, an antibiotic brefeldin A (BFA) has been shown to exhibit the growth inhibitory effect on human cancer cells. We thus investigated if BFA might inhibit proliferation of androgen-responsive prostate cancer LNCaP cells and also explored how it would be carried out, focusing on cell cycle and androgen receptor (AR).
- Publication
Journal of biomedical science, 2010, Vol 17, p5
- ISSN
1423-0127
- Publication type
Journal Article
- DOI
10.1186/1423-0127-17-5