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- Title
Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia.
- Authors
Kwon, Hyung-Min; Kim, YunHee; Yang, Seung-In; Kim, Yong-Ju; Lee, Seung-Hoon; Yoon, Byung-Woo
- Abstract
Geldanamycin (GA), a benzoquinone ansamycin, binds HSP90, releases heat shock factor 1 and induces heat shock proteins (HSPs). HSP70, a major molecular chaperone, protects the brain against ischemic injury through inhibition of apoptotic pathways in vivo and reduced matrix metalloproteinase 9 (MMP-9) after ischemia in vitro. We hypothesized that GA would protect brain from focal ischemia via induction of HSP70 and MMP suppression in vivo.
- Publication
Neurological research, 2008, Vol 30, Issue 7, p740
- ISSN
0161-6412
- Publication type
Journal Article
- DOI
10.1179/174313208X289615