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- Title
CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value.
- Authors
Solano-Genesta, Manuel; Tarín-Arzaga, Luz; Velasco-Ruiz, Ileana; Lutz-Presno, Julia A; González-Llano, Oscar; Mancías-Guerra, Consuelo; Rodríguez-Romo, Laura; Ruiz-Delgado, Guillermo J; Ruiz-Argüelles, Guillermo J; Jaime-Pérez, José Carlos; Gómez-Almaguer, David
- Abstract
Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value.
- Publication
Hematology (Amsterdam, Netherlands), 2012, Vol 17, Issue 2, p66
- ISSN
1607-8454
- Publication type
Journal Article
- DOI
10.1179/102453312X13221316477741