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- Title
Reporting of meta-analyses of randomized controlled trials with a focus on drug safety: an empirical assessment.
- Authors
Hammad, Tarek A; Neyarapally, George A; Pinheiro, Simone P; Iyasu, Solomon; Rochester, George; Dal Pan, Gerald
- Abstract
Due to the sparse nature of serious drug-related adverse events (AEs), meta-analyses combining data from several randomized controlled trials (RCTs) to evaluate drug safety issues are increasingly being conducted and published, influencing clinical and regulatory decision making. Evaluation of meta-analyses involves the assessment of both the individual constituent trials and the approaches used to combine them. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting framework is designed to enhance the reporting of systematic reviews and meta-analyses. However, PRISMA may not cover all critical elements useful in the evaluation of meta-analyses with a focus on drug safety particularly in the regulatory-public health setting.
- Publication
Clinical trials (London, England), 2013, Vol 10, Issue 3, p389
- ISSN
1740-7753
- Publication type
Journal Article
- DOI
10.1177/1740774513479467