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Title
Incorporating lower grade toxicity information into dose finding designs.
Authors
Iasonos, Alexia; Zohar, Sarah; O'Quigley, John
Abstract
Toxicity grades underlie the definition of a dose-limiting toxicity but in the majority of phase I designs, the information contained in the individual grades is not used. Some authors have argued that it may be more appropriate to consider a polytomous rather than dichotomous response.