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- Title
The net effect of alternative allocation ratios on recruitment time and trial cost.
- Authors
Vozdolska, Ralitza; Sano, Mary; Aisen, Paul; Edland, Steven D
- Abstract
Increasing the proportion of subjects allocated to the experimental treatment in controlled clinical trials is often advocated as a method of increasing recruitment rates and improving the performance of trials. The presumption is that the higher likelihood of randomization to the experimental treatment will be perceived by potential study enrollees as an added benefit of participation and will increase recruitment rates and speed the completion of trials. However, studies with alternative allocation ratios require a larger sample size to maintain statistical power, which may result in a net increase in time required to complete recruitment and a net increase in total trial cost.
- Publication
Clinical trials (London, England), 2009, Vol 6, Issue 2, p126
- ISSN
1740-7745
- Publication type
Journal Article
- DOI
10.1177/1740774509103485