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- Title
TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells.
- Authors
Chai, Y; Ito, Y; Han, J
- Abstract
Members of the transforming growth factor-beta (TGF-beta) superfamily regulate cell proliferation, differentiation, and apoptosis, and control the development and maintenance of most tissues. TGF-beta signal is transmitted through the phosphorylation of Smad proteins by TGF-beta receptor serine/threonine kinase. During craniofacial development, TGF-beta may regulate the fate specification of cranial neural crest cells. These cells are multipotent progenitors and capable of producing diverse cell types upon differentiation. Here we summarize evidence that TGF-beta ligands and their signaling intermediates have significant roles in patterning and specification of cranial neural crest cells. The biological function of TGF-beta is carried out through the regulation of transcriptional factors during embryogenesis.
- Publication
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 2003, Vol 14, Issue 2, p78
- ISSN
1544-1113
- Publication type
Journal Article
- DOI
10.1177/154411130301400202