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- Title
Rosiglitazone Reduces the Evolution of Experimental Periodontitis in the Rat.
- Authors
Paola, R. Di; Mazzon, E.; Maiere, D.; Zito, D.; Britti, D.; De Majo, M.; Genovese, T.; Cuzzocrea, S.
- Abstract
The peroxisome proliferator-activated receptor-γ (PPAR-γ) receptor appears to play a pivotal role in the regulation of cellular proliferation and inflammation. Recent evidence also suggests that rosiglitazone, a PPAR-γ agonist, reduces acute and chronic inflammation. We hypothesized that rosiglitazone would attenuate periodontal inflammation. In the present study, we investigated the effects of rosiglitazone in a rat model of ligature-induced periodontitis. At day 8, ligation significantly induced an increase in neutrophil infiltration, as well as of gingivomucosal tissue expression of iNOS, nitrotyrosine formation, and poly (ADP-ribose) polymerase activation. Ligation significantly increased Evans blue extravasation in gingivomucosal tissue and alveolar bone destruction. Intraperitoneal injection of rosiglitazone (10 mg/kg 10% DMSO daily for 8 days) significantly decreased all of the parameters of inflammation, as described above. Analysis of these data demonstrated that rosiglitazone exerted an anti-inflammatory role during experimental periodontitis, and was able to ameliorate the tissue damage associated with ligature-induced periodontitis.
- Publication
Journal of Dental Research, 2006, Vol 85, Issue 2, p156
- ISSN
0022-0345
- Publication type
Academic Journal
- DOI
10.1177/154405910608500208