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- Title
Survivin, a Potential Early Predictor of Tumor Progression in the Oral Mucosa.
- Authors
Muzio, L. Lo; Pannone, G.; Leonardi, R.; Staibano, S.; Mignogna, M. D.; De Rosa, G.; Kudo, Y.; Takata, T.; Altieri, D. C.
- Abstract
Survivin is a recently described apoptosis inhibitor selectively over-expressed in most tumors. Immunohistochemistry was used to investigate a potential role of survivin as an early predictor of malignant transformation in precancerous and cancerous lesions of the oral cavity. Survivin was present in 10/30 cases (33%) of oral precancerous lesions without malignant progression, and in 15/16 cases (94%) of oral precancerous lesions evolved into full-blown squamous cell carcinoma. Tumors that progressed from these precancerous lesions retained widespread survivin positivity (100%). Variations among group means were highly statistically significant (p < 0.001). No significant correlation was found between survivin expression and the degree of dysplasia. High expression of cytoplasmic/nuclear survivin is an early event during oral carcinogenesis and may provide a useful tool for the identification of precancerous lesions at higher risk of progression into invasive carcinoma.
- Publication
Journal of Dental Research, 2003, Vol 82, Issue 11, p923
- ISSN
0022-0345
- Publication type
Academic Journal
- DOI
10.1177/154405910308201115