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- Title
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.
- Authors
Hasaniya, Nahidh W; Premaratne, Shyamal; Zhang, Wayne W; Razzuk, Aziz; Abdul-Ghani, Ayman A; Dashwood, Roderick H; Eklof, Bo; Tinsley, Larry; McNamara, J Judson
- Abstract
Acute respiratory distress syndrome (ARDS) remains a major cause of morbidity and mortality. Oxygen-free radicals (OFRs) produced during ischemia and reperfusion (IR) have been implicated as the final common pathway in the pathogenesis of this syndrome. Spin traps have been shown to decrease IR injury in several animal lung models. The hydroxylamine, OXANOH (2-ethyl-2,5,5-trimethyl-3-oxazolidine) has been proposed as an ideal spin trap that would trap extra- and intracellular OFRs producing the stable radical, OXANO• (2-ethyl-2,5,5-trimethyl-3-oxazolidinoxyl). Electron microscopy was used to investigate whether OXANOH would protect against IR injury in the rabbit lung.
- Publication
Vascular and endovascular surgery, 2011, Vol 45, Issue 7, p581
- ISSN
1938-9116
- Publication type
Journal Article
- DOI
10.1177/1538574410390715