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- Title
Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple sclerosis.
- Authors
Furby, J; Hayton, T; Anderson, V; Altmann, D; Brenner, R; Chataway, J; Hughes, Rac; Smith, Kj; Miller, Dh; Kapoor, R
- Abstract
Neuroaxonal loss is a pathological substrate of disability in progressive multiple sclerosis (MS) and can be estimated in vivo by measuring tissue atrophy on magnetic resonance imaging (MRI). While there is some evidence that brain atrophy correlates better with disability than T2 lesion load in secondary progressive MS, the clinical relevance of atrophy within specific regions of the central nervous system requires further evaluation.
- Publication
Multiple sclerosis (Houndmills, Basingstoke, England), 2008, Vol 14, Issue 8, p1068
- ISSN
1352-4585
- Publication type
Journal Article
- DOI
10.1177/1352458508093617