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- Title
The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study.
- Authors
Abo-Krysha, N; Rashed, L
- Abstract
Iron is essential for virtually all types of cells and organisms. The significance of iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells. Iron imbalance is associated with proinflammatory cytokines and oxidative stress, which have been implicated in the pathogenesis of multiple sclerosis (MS). Transferrin receptor (TfR) is the major mediator of iron uptake. Its expression is increased to facilitate iron entrance into the cell. The increased serum level of soluble transferrin receptor (sTfR) may indicate an abnormal intracellular distribution of iron and a decrease in the cytoplasmic compartment.
- Publication
Multiple sclerosis (Houndmills, Basingstoke, England), 2008, Vol 14, Issue 5, p602
- ISSN
1352-4585
- Publication type
Journal Article
- DOI
10.1177/1352458507085550