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- Title
Antinuclear antibodies and response to IFNbeta-1a therapy in relapsing-remitting multiple sclerosis.
- Authors
Ciccarelli, O; Bagnato, F; Mainero, C; Salvetti, M; Paolillo, A; Gasperini, C; Bastianello, S; Pozzilli, C
- Abstract
We determined whether positive ANA was related to response to rIFNss-1a in 62 relapsing-remitting MS patients. According to the presence of antinuclear antibodies (ANA) at baseline and during the first 6 months of treatment, patients were sorted in different groups. The clinical and MRI outcome during short-term (6 months) and long-term (24 months) treatment period was not statistically different between the groups. Therefore, the response to IFNbeta-1a seems not to be influenced by ANA occurrence either before or during treatment. When the analysis was extended to other autoantibodies (i. e. antithyroid, anticardiolipin) similar results were obtained.
- Publication
Multiple sclerosis (Houndmills, Basingstoke, England), 2000, Vol 6, Issue 3, p137
- ISSN
1352-4585
- Publication type
Journal Article
- DOI
10.1177/135245850000600301