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- Title
Effect of ticlopidine on monocyte-derived microparticles and activated platelet markers in diabetes mellitus.
- Authors
Shouzu, Akira; Nomura, Shosaku; Omoto, Seitaro; Hayakawa, Takashi; Nishikawa, Mitsushige; Iwasaka, Toshiji
- Abstract
Platelet-derived microparticles, activated platelets, and monocyte-derived microparticles were measured in 73 patients with diabetes mellitus. A comparative study of these parameters was performed before and after administration of ticlopidine. The number of platelet-derived microparticles and activated platelets was increased significantly in diabetic patients. Monocyte-derived microparticles were also increased significantly. After administration of ticlopidine, platelet-derived microparticles and activated platelets corrected positively, not only CD62P- and CD63-positive platelets, but also platelet-derived microparticles and monocyte-derived microparticles showed a significant decrease. These data suggest that in patients with diabetes, platelet-derived microparticles and activated platelets stimulate the activation of monocytes and promote the production of monocyte-derived microparticles, and that ticlopidine is useful for hypercoagulabillity in diabetic patients.
- Publication
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2004, Vol 10, Issue 2, p167
- ISSN
1076-0296
- Publication type
Journal Article
- DOI
10.1177/107602960401000207