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- Title
Association of CD247 with systemic lupus erythematosus in Asian populations.
- Authors
Li, R; Yang, W; Zhang, J; Hirankarn, N; Pan, H-F; Mok, C C; Chan, T M; Wong, R W S; Mok, M Y; Lee, K W; Wong, S N; Leung, A M H; Li, X-P; Avihingsanon, Y; Lee, T L; Ho, M H K; Lee, P P W; Wong, W H S; Wong, C-M; Ng, I O L; Yang, J; Li, P H; Zhang, Y; Zhang, L; Li, W; Baum, L; Kwan, P; Rianthavorn, P; Deekajorndej, T; Suphapeetiporn, K; Shotelersuk, V; Garcia-Barceló, M-M; Cherny, S S; Tam, P K-H; Sham, P C; Lau, C S; Shen, N; Lau, Y l; Ye, D-Q
- Abstract
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. CD247 (CD3Z, TCRZ) plays a vital role in antigen recognition and signal transduction in antigen-specific immune responses, and is known to be involved in SLE pathogenesis. Weak disease association was reported for genetic variants in this gene in Caucasian studies for SLE, Crohn's disease and systemic sclerosis, but its role as a genetic risk factor was never firmly established.
- Publication
Lupus, 2012, Vol 21, Issue 1, p75
- ISSN
1477-0962
- Publication type
Journal Article
- DOI
10.1177/0961203311422724