We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An assessment of bone fluoride and osteosarcoma.
- Authors
Kim, F M; Hayes, C; Williams, P L; Whitford, G M; Joshipura, K J; Hoover, R N; Douglass, C W; National Osteosarcoma Etiology Group
- Abstract
The association between fluoride and risk for osteosarcoma is controversial. The purpose of this study was to determine if bone fluoride levels are higher in individuals with osteosarcoma. Incident cases of osteosarcoma (N = 137) and tumor controls (N = 51) were identified by orthopedic physicians, and segments of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. Logistic regression adjusted for age and sex and potential confounders of osteosarcoma was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, and a history of broken bones was 1.33 (95% CI: 0.56-3.15). No significant association between bone fluoride levels and osteosarcoma risk was detected in our case-control study, based on controls with other tumor diagnoses.
- Publication
Journal of dental research, 2011, Vol 90, Issue 10, p1171
- ISSN
1544-0591
- Publication type
Journal Article
- DOI
10.1177/0022034511418828