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- Title
Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2.
- Authors
Souza, P P C; Palmqvist, P; Lundgren, I; Lie, A; Costa-Neto, C M; Lundberg, P; Lerner, U H
- Abstract
The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-alpha (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysac-charide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts.
- Publication
Journal of dental research, 2010, Vol 89, Issue 8, p802
- ISSN
1544-0591
- Publication type
Journal Article
- DOI
10.1177/0022034510366898