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- Title
Efficacy of amlodipine in pediatric bone marrow transplant patients.
- Authors
Khattak, S; Rogan, J W; Saunders, E F; Theis, J G; Arbus, G S; Koren, G
- Abstract
The calcium antagonist amlodipine may have the potential for expanded use in children owing to its physiochemistry and pharmacokinetic profile that facilitates once-daily dosing in a liquid formulation. Its safety and efficacy have not been previously evaluated in children. A retrospective analysis of 15 pediatric bone marrow transplant patients who had amlodipine incorporated into their antihypertensive drug regimen reveals significantly lower blood pressure as compared with baseline therapy (123.5+/-2.1 mmHg and 117.2+/-2.2 mmHg, systolic blood pressure before and during amlodipine, P<0.05; 81.5+/-1.8 mmHg and 75.5+/-2.6 mmHg, diastolic blood pressure before and during amlodipine, P<0.05). Amlodipine provided improved blood pressure control in this cohort and may provide a valuable pharmacologic alternative for treatment of pediatric hypertension.
- Publication
Clinical pediatrics, 1998, Vol 37, Issue 1, p31
- ISSN
0009-9228
- Publication type
Journal Article
- DOI
10.1177/000992289803700105