We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease.
- Authors
Koufman, Jamie A; Johnston, Nikki
- Abstract
At the cellular level, tissue-bound pepsin is fundamental to the pathophysiologic mechanism of reflux disease, and although the thresholds for laryngeal damage in laryngopharyngeal reflux and for esophageal damage in gastroesophageal reflux disease differ, both forms of damage are due to pepsin, which requires acid for its activation. In addition, human pepsin remains stable at pH 7.4 and may be reactivated by hydrogen ions from any source. Thus, most tap and bottled waters (typically pH 6.7 to 7.4) would not be expected to affect pepsin stability. The purposes of these in vitro studies were to investigate whether artesian well water containing natural bicarbonate (pH 8.8) might irreversibly denature (inactivate) human pepsin, and to establish its potential acid-buffering capacity.
- Publication
The Annals of otology, rhinology, and laryngology, 2012, Vol 121, Issue 7, p431
- ISSN
0003-4894
- Publication type
Journal Article
- DOI
10.1177/000348941212100702