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- Title
Low-acid diet for recalcitrant laryngopharyngeal reflux: therapeutic benefits and their implications.
- Authors
Koufman, Jamie A
- Abstract
Laryngopharyngeal reflux (LPR) is an expensive, high-prevalence disease with a high rate of medical treatment failure. In the past, it was mistakenly believed that pepsin was inactive above pH 4; however, human pepsin has been reported to be active up to pH 6.5. In addition, it has been shown by Western blot analysis that laryngeal biopsy samples from patients with symptomatic LPR have tissue-bound pepsin. The clinical impact of a low-acid diet on the therapeutic outcome in LPR has not been previously reported. To provide data on the therapeutic benefit of a strict, virtually acid-free diet on patients with recalcitrant, proton pump inhibitor (PPI)-resistant LPR, I performed a prospective study of 20 patients who had persistent LPR symptoms despite use of twice-daily PPIs and an H2-receptor antagonist at bedtime.
- Publication
The Annals of otology, rhinology, and laryngology, 2011, Vol 120, Issue 5, p281
- ISSN
0003-4894
- Publication type
Journal Article
- DOI
10.1177/000348941112000501